5-Nitro-1H-indole-2-carboxylic acid propylamide → 5-Amino-1H-indole-2-carboxylic acid propylamide

HRID 450720노트

반응식

HRID 450720 반응식
[CH2:1]([NH:4][C:5]([C:7]1[NH:8][C:9]2[C:14]([CH:15]=1)=[CH:13][C:12]([N+:16]([O-])=O)=[CH:11][CH:10]=2)=[O:6])[CH2:2][CH3:3]>CCO.[Pd]>[CH2:1]([NH:4][C:5]([C:7]1[NH:8][C:9]2[C:14]([CH:15]=1)=[CH:13][C:12]([NH2:16])=[CH:11][CH:10]=2)=[O:6])[CH2:2][CH3:3]

참가 물질

4

반응물 1

HCID 670239755-Nitro-1H-indole-2-carboxylic acid propylamide

생성물 1

HCID 620571415-Amino-1H-indole-2-carboxylic acid propylamide수율 95%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매2회

실험 절차

To a solution of 5-nitro-1H-indole-2-carboxylic acid propylamide (2.94 g, 11.9 mmol) in EtOH (150 ml) a suspension of palladium on charcoal (10%, 1 g) in EtOH was added. The mixture was hydrogenated at atmospheric pressure. After filtration and removal of the solvents in vacuo the product was obtained as a yellow powder (2.46 mg, 95%).

후처리

  1. additionwas added
  2. filtrationAfter filtration and removal of the solvents in vacuo the product

출처 및 근거

ORD 기록
ord-630127751cc1404dbcd018eddda7be57
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486984B2

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