참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | N,N-Dimethylaniline | HCID 949 | — |
| 반응물 | 4-(Propan-2-yl)benzene-1-sulfonyl chloride | HCID 2734882 | — |
| 반응물 | 2-Nitro-4-phenylenediamine | HCID 4338370 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | N-(4-Amino-3-nitro-phenyl)-4-isopropyl-benzenesulfonamide | HCID 27993411 | 55.4% |
반응 단계
To a mixture of 2-nitro-benzene-1,4-diamine (10 g, 65.30 mmol) and N,N-dimethylaniline (8.7 g, 71.83 mmol) in acetonitrile (310 ml) at 0° C. 4-isopropyl-benzenesulfonylchloride (13.85 g, 63.34 mmol) was added over a period of 1 h. The mixture was stirred at 0° C. for 1 h and for 16 h at room temperature. After concentrating the mixture in vacuo the obtained oil was triturated with water. The precipitate was collected, washed with ethanol and dried in vacuo to give the product as a yellow powder (11.76 g, 54%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08486984B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_07 |
|---|
| ORD ID | ord-d1517fabb6114385b7dc8398287ec5a8 |
|---|
| 출처 메모 | uspto-grants-2013_07 |
|---|
