Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 45083생성일: 2026년 10월 23일
5-Hydroxyindole → (+/-)-4-(1H-Indol-5-yloxy)-8-methyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester
https://huagongshe.com/ko/reaction/45083
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-Hydroxyindole | HCID 16054 | — |
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | tert-Butyl 4-chloro-8-methyl-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate | HCID 59394669 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | (+/-)-4-(1H-Indol-5-yloxy)-8-methyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester | HCID 59394465 | — |
반응 단계
To a solution of 4-chloro-8-methyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester (228 mg, 0.80 mmol), 5-hydroxyindole (139 mg, 1.05 mmol) and MeCN (5 mL) is added DBU (0.15 mL, 1.05 mmol). The resulting misture is heated at 80° C. for 4 h. The reaction is then concentrated in vacuo and the residue separated via FCC (5-60% EtOAc/heptane). MS (ESI) m/z 381.1 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08541432B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-d00b4fc61fe247708747fde4069fb94b |
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| 출처 메모 | uspto-grants-2013_09 |
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