Potassium Carbonate → omega-(2-Cyano-4-chlorophenoxy)-2-benzyloxy-acetophenone

HRID 450838노트

반응식

HRID 450838 반응식
C(=O)([O-])[O-].[K+].[K+].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([C:15]#[N:16])[CH:9]=1.Br[CH:18]([O:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:20]>CN(C=O)C>[C:15]([C:10]1[CH:9]=[C:8]([Cl:7])[CH:13]=[CH:12][C:11]=1[O:14][CH:18]([O:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:20])#[N:16]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 27774205-Chloro-2-hydroxybenzonitrileHCID 20153830omega-Bromo-2-benzyloxy-acetophenone

생성물 1

HCID 68535637omega-(2-Cyano-4-chlorophenoxy)-2-benzyloxy-acetophenone

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A suspension of potassium carbonate (0.06 g, 4.0 mmol), 4-chloro-2-cyanophenol (0.25 g, 1.6 mmol) and ω-bromo-2-benzyloxy-acetophenone (0.49 g, 1.6 mmol) in dry DMF (10 ml) is stirred at room temperature for 20 h. After evaporating the solvent under reduced pressure the residue is taken up in ethyl acetate. The solution is washed with water, dried over sodium sulfate and evaporated under reduced pressure. The residue is purified by silical gel column chromatography to yield the title compound.

후처리

  1. customAfter evaporating the solvent under reduced pressure the residue
  2. washThe solution is washed with water
  3. dry with materialdried over sodium sulfate
  4. customevaporated under reduced pressure
  5. customThe residue is purified by silical gel column chromatography

출처 및 근거

ORD 기록
ord-d607c6706b354f9e9d4543951294f806
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486996B2

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