3-Amino-5-chloro-2-(2-benzyloxybenzoyl)-benzofuran → 3-Amino-5-chloro-2-(2-hydroxybenzoyl)-benzofuran

HRID 450841노트

반응식

HRID 450841 반응식
[NH2:1][C:2]1[C:6]2[CH:7]=[C:8]([Cl:11])[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:12](=[O:27])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19]CC1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[NH2:1][C:2]1[C:6]2[CH:7]=[C:8]([Cl:11])[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:12](=[O:27])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[OH:19]

참가 물질

4

반응물 1

HCID 113034533-Amino-5-chloro-2-(2-benzyloxybenzoyl)-benzofuran

생성물 1

HCID 587073613-Amino-5-chloro-2-(2-hydroxybenzoyl)-benzofuran

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

3-Amino-5-chloro-2-(2-benzyloxybenzoyl)-benzofuran (Example 1, 0.5 g, 1.3 mmol) in ethyl acetate (15 ml) is stirred at room temperature under an atmosphere of hydrogen in the presence of palladium on charcoal (0.025 g). After 3 h the mixture is filtered over Celite® and evaporated to dryness. Purification of the residue by chromatography yields the title compound, having a m.p. of 208-210° C.

후처리

  1. filtrationAfter 3 h the mixture is filtered over Celite®
  2. customevaporated to dryness
  3. customPurification of the residue by chromatography

출처 및 근거

ORD 기록
ord-20fa3f48fa274d5ba5b0c9b6540c4feb
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486996B2

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