4-Chloropyridine → HCID 69284462, 화합물

HRID 450852

반응식

HRID 450852 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]([O:12]CC)=O)=[CH:7][C:6]=2[CH:15]=1.Cl[C:17]1[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=1>C1COCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10](=[O:12])[C:22]3[CH:17]=[CH:3][CH:2]=[CH:15][C:21]=3[N:20]3[CH2:7][CH2:8][O:9][CH2:18][CH2:19]3)=[CH:7][C:6]=2[CH:15]=1

참가 물질

4

반응물 2

HCID 122884-ChloropyridineHCID 2799299Ethyl 5-chlorobenzofuran-2-carboxylate

생성물 1

HCID 69284462HCID 69284462, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of ethyl 5-chlorobenzofuran-2-carboxylate (350 mg, 1.56 mmol) in THF (10 ml) is added at −70° C. to a THF solution of lithiated 4-chloropyridine (1.8 mmol prepared according to G. Quéguiner et al., Synthesis 1986, 886-891). The mixture is allowed to reach room temperature within 16 hours before quenching with acetic acid. The product is extracted with chloroform. Drying and chromatography on silicagel gives the title compound.

후처리

  1. custombefore quenching with acetic acid
  2. extractionThe product is extracted with chloroform
  3. customDrying

출처 및 근거

ORD 기록
ord-87f9061cd16240e8b1cc4d37ba8988e8
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486996B2

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