Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 45087생성일: 2026년 10월 23일
5-Hydroxyindole → 4-(1H-indol-5-yloxy)-6-methyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester
https://huagongshe.com/ko/reaction/45087
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-Hydroxyindole | HCID 16054 | — |
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | Tert-butyl 4-chloro-6-methyl-5,8-dihydropyrido[3,4-D]pyrimidine-7(6H)-carboxylate | HCID 59394353 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-(1H-indol-5-yloxy)-6-methyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester | HCID 59394118 | — |
반응 단계
A solution of (±)-4-chloro-6-methyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester (220 mg, 0.77 mmol), 5-hydroxy indole (155 mg, 1.16 mmol) and MeCN (10 mL) is treated with DBU (0.2 mL, 1.16 mmol) and heated at 80° C. for 4 h. The volume is reduced in vacuo and the residue is separated via FCC (5-90% EtOAc/heptane) to give the title compound. MS (ESI) m/z 381.3 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08541432B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-22c57473bae94ed3b49e8253b9233a65 |
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| 출처 메모 | uspto-grants-2013_09 |
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