Triethylamine → (2-Isocyanatocyclopropyl)benzene

HRID 450966

반응식

HRID 450966 반응식
[C:1]1([CH:7]2[CH2:9][CH:8]2C(O)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([N:15]([CH2:18]C)CC)C.C1C=CC(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:27])=CC=1>C1(C)C=CC=CC=1>[N:15]([CH:8]1[CH2:9][CH:7]1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[C:18]=[O:27]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 703232-Phenylcyclopropane-1-carboxylic acidHCID 199401P,P-Diphenylphosphinic azide

생성물 1

HCID 582709(2-Isocyanatocyclopropyl)benzene수율 81.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 2-phenylcyclopropanecarboxylic acid (1.0 g, 6.17 mmol) in dry toluene (20 mL) was added triethylamine (934 mg, 9.26 mmol) and DPPA (2.0 g, 7.41 mmol) under N2, and the reaction mixture was refluxed for 3 h. The solution was concentrated to give (2-isocyanatocyclopropyl)benzene (800 mg), which was used for the next step without further purification.

후처리

  1. temperaturethe reaction mixture was refluxed for 3 h
  2. concentrationThe solution was concentrated

출처 및 근거

ORD 기록
ord-7019917bd13d4f64a7fdaed93ff7742c
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08487094B2

연결된 노트

불러오는 중…