Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphosgene → [(1S)-1-isocyanatopropyl]benzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphosgene | HCID 94429 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | (1S)-1-phenylpropan-1-amine | HCID 6993773 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | [(1S)-1-isocyanatopropyl]benzene | HCID 7018275 | 88% |
반응 단계
To a solution of (S)-1-phenylpropan-1-amine (3.00 g, 14 mmol) in the mixture of methylene chloride (50 mL) and saturated NaHCO3 (50 mL) was added triphosgene (1.40 g, 4.60 mmol) at 0° C. The mixture was stirred for 15 minutes. The organic phase was separated, dried and concentrated to give (S)-(1-isocyanatopropyl)benzene (3.0 g, 88%). 1H NMR (CDCl3): δ=0.93 (q, 3H), 1.81 (m, 2H), 4.50 (m, 1H), 7.13 (m, 2H), 7.22 (m, 1H), 7.50 (m, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08487094B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-4e09c8a2083e4ec1b2f69852401c0e40 |
| 출처 메모 | uspto-grants-2013_07 |