Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1'-Carbonyldiimidazole → HCID 59394510, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 5-Amino-2-methoxybenzotrifluoride | HCID 600705 | — |
| 반응물 | 1H-Indole, 5-[[6-[(phenylmethoxy)methyl]-4-pyrimidinyl]oxy]- | HCID 59394260 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 59394510 | HCID 59394510 | — |
반응 단계
To a solution of 5-(6-(benzyloxymethyl)pyrimidin-4-yloxy)-1H-indole (0.8 g, 2.41 mmol) in 35 mL of DCE, CDI (1.17 g, 7.24 mmol) is added followed by TEA (1 mL, 7.24 mmol). Mixture is stirred at rt overnight and then 4-methoxy-3-(trifluoromethyl)aniline (1.38 g, 7.24 mmol) is added followed by stirring for 4 days. The reaction is diluted with DCM, washed with saturated aqueous NaHCO3 (×2), brine, and the organic layer is dried over Na2SO4. After concentration, the residue is purified by FCC (5-60% EtOAc/heptane) to give the title compound. MS (ESI) m/z 549.1 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541432B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-5f07ad80665e4cda83646908f72ce0a4 |
| 출처 메모 | uspto-grants-2013_09 |