Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Heptyne → N-(2-Hept-1ynyl-phenyl)-acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Heptyne | HCID 12350 | — |
| 반응물 | N-Acetyl-O-p-toluenesulfonyl-2-aminophenol | HCID 572553 | — |
| 용매 | Ethylacetate heptane | HCID 21899848 | — |
| 생성물 | N-(2-Hept-1ynyl-phenyl)-acetamide | HCID 25221491 | — |
반응 단계
This product was prepared from toluene-4-sulfonic acid 2-acetylamino-phenyl ester and 1-heptyne following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane/EtOAc 8:2; yield (92 mg, 80%); 1H NMR δ (CDCl3): 8.47 (d, J=8.51 Hz, 1H), 7.93 (br s, 1H), 7.36 (dm, 1H), 7.31-7.23 (m, 1H), 7.02 (t, J=7.22 Hz, 1H), 2.53 (t, J=7.08 Hz, 2H), 2.21 (s, 3H), 1.63 (p, J=7.11 Hz, 2H), 1.48-1.3 (m, 4H), 0.92 (t, J=7.2 Hz, 3H); LCMS m/z: 229.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08487109B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-7fd335d18fb142e68d695073438d98ff |
| 출처 메모 | uspto-grants-2013_07 |