Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenylacetylene → Acetamide, N-[2-(phenylethynyl)phenyl]-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenylacetylene | HCID 10821 | — |
| 반응물 | N-Acetyl-O-p-toluenesulfonyl-2-aminophenol | HCID 572553 | — |
| 용매 | Ethylacetate heptane | HCID 21899848 | — |
| 생성물 | Acetamide, N-[2-(phenylethynyl)phenyl]- | HCID 2749414 | — |
반응 단계
This product was prepared from toluene-4-sulfonic acid 2-acetylamino-phenyl ester and ethynyl-benzene following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane/EtOAc 9:1; yield (60 mg, 50%); 1H NMR δ (CDCl3): 8.39 (d, J=8.55 Hz, 1H), 7.9 (br s, 1H), 7.59-7.67 (m, 2H), 7.58-7.52 (m, 2H), 7.41-7.35 (m, 3H), 7.02 (t, J=7.22 Hz, 1H), 2.21 (s, 3H); LCMS m/z: 235.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08487109B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-e323057205b2480987423b3ad85724f1 |
| 출처 메모 | uspto-grants-2013_07 |