Dietylaminopropin → HCID 11436489, 화합물

HRID 451257

반응식

HRID 451257 반응식
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1OS(C1C=CC(C)=CC=1)(=O)=O)(=[O:3])[CH3:2].[CH2:22]([N:24]([CH2:28][CH3:29])[CH2:25][C:26]#[CH:27])[CH3:23]>CCCCCCC.CCOC(C)=O>[CH2:22]([N:24]([CH2:28][CH3:29])[CH2:25][C:26]#[C:27][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[NH:4][C:1](=[O:3])[CH3:2])[CH3:23]

참가 물질

4

반응물 2

HCID 20010DietylaminopropinHCID 572553N-Acetyl-O-p-toluenesulfonyl-2-aminophenol

생성물 1

HCID 11436489HCID 11436489, 화합물

시약·촉매·용매 1

HCID 21899848Ethylacetate heptane용매

실험 절차

This product was prepared from toluene-4-sulfonic acid 2-acetylamino-phenyl ester and diethyl-prop-2-ynyl-amine following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane/EtOAc 8:2; yield (73 mg, 60%); 1H NMR δ (CDCl3): 8.47 (d, J=8.52 Hz, 1H), 7.93 (br s, 1H), 7.36 (dm, 1H), 7.31-7.23 (m, 1H), 7.02 (t, J=7.24 Hz, 1H), 3.54 (s, 2H), 2.62 (q, J=7.13 Hz, 4H), 2.21 (s, 3H), 1.11 (t, J=7.11 Hz, 6H); LCMS m/z: 244.

후처리

  1. customyield (73 mg, 60%)

출처 및 근거

ORD 기록
ord-458e3fdf74bd4706859f120a7bb7002b
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08487109B2

연결된 노트

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