2-nitro-7-phenyl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]oxazine → 7-Phenyl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]oxazin-2-ylamine

HRID 451493노트

반응식

HRID 451493 반응식
[N+:1]([C:4]1[N:18]=[C:7]2[O:8][CH2:9][CH2:10][CH:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:6]2[N:5]=1)([O-])=O>C(OCC)(=O)C.[Pd]>[C:12]1([CH:11]2[CH2:10][CH2:9][O:8][C:7]3=[N:18][C:4]([NH2:1])=[N:5][N:6]23)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

참가 물질

4

반응물 1

HCID 673366942-nitro-7-phenyl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]oxazine

생성물 1

HCID 673361667-Phenyl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]oxazin-2-ylamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2-nitro-7-phenyl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]oxazine (174 mg, 707 μmol) in ethyl acetate (7 mL) was added 10% Pd on carbon (17.4 mg, 164 μmol). The reaction was hydrogenated at room temperature under an atmosphere of hydrogen over night. The catalyst was filtered off and washed with ethyl acetate. The title compound was obtained as a white solid (143.3 mg, 94%) after stirring with diethyl ether.

후처리

  1. waitThe reaction was hydrogenated at room temperature under an atmosphere of hydrogen over night
  2. filtrationThe catalyst was filtered off
  3. washwashed with ethyl acetate

출처 및 근거

ORD 기록
ord-e80a5848181c40dabc3d8c844b7d8edf
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486967B2

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