tert-Butyl 4-(benzylamino)-3,3-difluoropiperidine-1-carboxylate → tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate
반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14]CC2C=CC=CC=2)[C:10]([F:23])([F:22])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH2:14])[C:10]([F:23])([F:22])[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]참가 물질
4
실험 절차
A suspension of 4-benzylamino-3,3-difluoro-piperidine-1-carboxylic acid tert-butyl ester (830 mg, 2.54 mmol), Pd/C (81.2 mg, 76.3 μmol) in MeOH (30 mL) was hydrogenated at room temperature for 14 hours. The catalyst was filtered off, washed thoroughly with MeOH and the solvents were evaporated. The title compound was obtained as colorless oil (601 mg, 100%).
후처리
- filtrationThe catalyst was filtered off
- washwashed thoroughly with MeOH
- customthe solvents were evaporated
출처 및 근거
- ORD 기록
- ord-66d74a7158f648e38ec52602af190b5d
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08486967B2
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