1-(4-T-Butylphenyl)-3-chloropropan-1-one → 5-Tert-butyl-2,3-dihydroinden-1-one

HRID 451587

반응식

HRID 451587 반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:15])[CH2:12][CH2:13]Cl)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>S(=O)(=O)(O)O>[C:1]([C:5]1[CH:10]=[C:9]2[C:8](=[CH:7][CH:6]=1)[C:11](=[O:15])[CH2:12][CH2:13]2)([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 1

HCID 222283931-(4-T-Butylphenyl)-3-chloropropan-1-one

생성물 1

HCID 110305765-Tert-butyl-2,3-dihydroinden-1-one

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

반응 조건

온도
95 °C

실험 절차

1-(4-tert-Butylphenyl)-3-chloro-1-propanone (22.25 g, 99 mmol) was dissolved in concentrated sulfuric acid (100 ml) and heated on a water bath at 95° C. for 2.5 hours. The reaction mixture was cooled, poured onto ice, and extracted with diethyl ether. The combined organic extracts were washed with saturated aqueous sodium bicarbonate, dried with magnesium sulfate, and the filtrate was evaporated under reduced pressure to provide the title compound which was used without further purification in the next step.

후처리

  1. temperatureThe reaction mixture was cooled
  2. additionpoured onto ice
  3. extractionextracted with diethyl ether
  4. washThe combined organic extracts were washed with saturated aqueous sodium bicarbonate
  5. dry with materialdried with magnesium sulfate
  6. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-04a17c82613e47bba8fff76f66057048
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08487116B2

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