O-Methylhydroxylamine hydrochloride → 5-tert-butyl-1-indanone O-methyloxime

HRID 451588

반응식

HRID 451588 반응식
[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=O)[CH2:9][CH2:8]2)([CH3:4])([CH3:3])[CH3:2].Cl.[CH3:16][O:17][NH2:18]>N1C=CC=CC=1>[CH3:16][O:17][N:18]=[C:10]1[C:11]2[C:7](=[CH:6][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:13][CH:12]=2)[CH2:8][CH2:9]1

참가 물질

4

반응물 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 110305765-Tert-butyl-2,3-dihydroinden-1-one

생성물 1

HCID 730474605-tert-butyl-1-indanone O-methyloxime

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

5-tert-Butyl-1-indanone (13.41 g, 71.23 mmol) and methoxyamine hydrochloride (6.68 g, 80 mmol) were dissolved in pyridine (75 ml) and stirred at ambient temperature for 16 hours. The mixture was evaporated under reduced pressure and the residue was partitioned between water and diethyl ether (X2). The combined organic layers were washed with 1N aqueous hydrochloric acid, dried with magnesium sulfate, and the filtrate was evaporated under reduced pressure to provide the title compound which was used without further purification in the next step.

후처리

  1. customThe mixture was evaporated under reduced pressure
  2. customthe residue was partitioned between water and diethyl ether (X2)
  3. washThe combined organic layers were washed with 1N aqueous hydrochloric acid
  4. dry with materialdried with magnesium sulfate
  5. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-37018b6dac7f488f91d18c23f04e9289
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08487116B2

연결된 노트

불러오는 중…