Piperidine → HCID 67187268, 화합물

HRID 451616노트

반응식

HRID 451616 반응식
F[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[C:7](=[O:12])[CH2:6][CH2:5]2.[NH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>N1C=CC=CC=1>[F:11][C:10]1[CH:9]=[C:8]2[C:4]([CH2:5][CH2:6][C:7]2=[O:12])=[CH:3][C:2]=1[N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 117689445,6-Difluoro-1-indanone

생성물 1

HCID 67187268HCID 67187268, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

5,6-difluoro-indan-1-one (2.49 g, 14.8 mmol) and piperidine (4.4 ml, 3.78 g, 44.4 mmol) were dissolved in pyridine (10 ml) and heated to reflux for 16 hours. The reaction was cooled, and the solvent removed under vacuum. The residue was taken in ethyl ether, washed with 1N aqueous sodium hydroxide and water, dried with magnesium sulfate, and the solvent removed under vacuum to give the desired product as 2.97 g of a black solid that was used without further purification. 1H NMR (300 MHz, CDCl3) 7.32 (d, 1H), 6.88 (d, 1H), 3.19 (m, 4H), 3.03 (m, 2H), 2.66 (m, 2H), 1.73 (m, 4H), 1.62 (m, 2H). MS (CSI) m/e 234 (M+H)+

후처리

  1. temperatureheated
  2. temperatureto reflux for 16 hours
  3. temperatureThe reaction was cooled
  4. customthe solvent removed under vacuum
  5. washwashed with 1N aqueous sodium hydroxide and water
  6. dry with materialdried with magnesium sulfate
  7. customthe solvent removed under vacuum

출처 및 근거

ORD 기록
ord-b394b8a175d84154a5a9758629da0424
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08487116B2

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