Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triacetoxyperiodinane → 1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triacetoxyperiodinane | HCID 159087 | — |
| 반응물 | 1-Tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate | HCID 5148299 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate | HCID 4251853 | — |
반응 단계
To a solution of 4-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (5 g, 20.4 mmol) in DCM (100 mL), Dess-Martin periodinane (12.97 g, 30.6 mmol) is added. After completion of the reaction as judged by TLC the reaction is quenched with sat NaHCO3, washed with sat sodium thiosulfate and extracted with DCM. The organics are dried and evaporated and used crude in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541432B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-7e231e86ac7d47e0a5156a0df52cfadb |
| 출처 메모 | uspto-grants-2013_09 |