Ethanaminium, N,N,N-triethyl-, fluoride (1:1) → HCID 10988904, 화합물

HRID 451762

반응식

HRID 451762 반응식
C[Si](C)(C)CCOC([NH:8][CH2:9][C@@H:10]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=O.[N+](CC)(CC)(CC)CC.[F-]>CC#N>[NH2:8][CH2:9][C@@H:10]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:23])([CH3:22])[CH3:24])[CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

참가 물질

4

반응물 2

HCID 69582Ethanaminium, N,N,N-triethyl-, fluoride (1:1)HCID 59382914HCID 59382914, 화합물

생성물 1

HCID 10988904HCID 10988904, 화합물수율 85.9%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
60 °C

실험 절차

To a stirred solution of (S)-tert-butyl 1-(2-(trimethylsilyl)ethoxycarbonylamino)-3-cyclohexylpropan-2-ylcarbamate (6.55 g, 15.4 mmol) in MeCN (100 mL) was added Et4NF (7.5 g, 50 mmol). The mixture was stirred overnight at rt and at 60° C. for 7 h. The mixture was concentrated and the oily residue was taken up in EtOAc (175 mL). The mixture was washed with water (2×50 mL) and brine (50 mL) and dried over Na2SO4. Removal of the solvent afforded (S)-tert-butyl 1-amino-3-cyclohexylpropan-2-ylcarbamate (3.39 g, 80%) as a syrup.

후처리

  1. concentrationThe mixture was concentrated
  2. washThe mixture was washed with water (2×50 mL) and brine (50 mL)
  3. dry with materialdried over Na2SO4
  4. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-18651ba18c464d10a01bba32b765863c
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08487108B2

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