Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 3-Cyclohexylpropyl-(ethyl)carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | 2,5-Dioxopyrrolidin-1-yl 2-(trimethylsilyl)ethyl carbonate | HCID 5018386 | — |
| 반응물 | (S)-tert-butyl 1-cyclohexyl-3-(ethylamino)propan-2-ylcarbamate | HCID 59201304 | — |
| 생성물 | 3-Cyclohexylpropyl-(ethyl)carbamate | HCID 131730716 | 45% |
반응 단계
To a solution of (S)-tert-butyl 1-cyclohexyl-3-(ethylamino)propan-2-ylcarbamate (338 mg) and TeocOSu (386 mg, 1.49 mmol) in THF was added TEA (0.6 mL). The resulting solution was stirred at rt for 30 min and evaporated. The residue was purified through chromatography on silica gel to give (S)-2-(trimethylsilyl)ethyl 2-(N-tert-butoxycarbonyl)amino)-3-cyclohexylpropyl-(ethyl)carbamate (287 mg, 45% over 2 steps).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08487108B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-e0de30f8a9114fa4950dea2fb477176d |
| 출처 메모 | uspto-grants-2013_07 |