Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonium Chloride → (S)-tert-butyl 1-cyclohexyl-3-hydroxypentan-2-ylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | (S)-tert-butyl 1-cyclohexyl-3-oxopentan-2-ylcarbamate | HCID 15730499 | — |
| 용매 | MeOH tetrahydrofuran | HCID 21899815 | — |
| 생성물 | (S)-tert-butyl 1-cyclohexyl-3-hydroxypentan-2-ylcarbamate | HCID 59201568 | — |
반응 단계
To a solution of (S)-tert-butyl 1-cyclohexyl-3-oxopentan-2-ylcarbamate in THF/MeOH (604/15 mL) at 0° C. was carefully added NaBH4 (630 mg, 16.66 mmol). After 20 min, sat. aq. NH4Cl was added to quench the reaction, and extracted with EtOAc, washed with brine, dried over Na2SO4, filtered, and concentrated to give (S)-tert-butyl 1-cyclohexyl-3-hydroxypentan-2-ylcarbamate (4.77 g, 96%, in a ratio of 40:60) as a white solid. MS ESI +ve m/z 286 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08487108B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-0db4cce6a1e04c7090574e707c3d1e2a |
| 출처 메모 | uspto-grants-2013_07 |