참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tributylstannane | HCID 5948 | — |
| 반응물 | Azobisisobutyronitrile | HCID 6547 | — |
| 반응물 | Z-Dehydro-Ala-OMe | HCID 3525700 | — |
| 반응물 | 1-Bromo-1-methylcyclohexane | HCID 12502129 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | Methyl 2-(benzyloxycarbonylamino)-3-(1-methylcyclohexyl)propanoate | HCID 59201682 | — |
반응 단계
A mixture of 1-bromo-1-methylcyclohexane (7.200 g, 3.0 equiv), tributyltin hydride (8 mL, 2.2 equiv), methyl 2-(benzyloxycarbonylamino)acrylate (3.120 g, 13.26 mmol, 1.0 equiv), and 2,2′-azobisisobutyronitrile (0.370 g, 0.17 equiv) in benzene (30 mL) was heated at 100° C. for 6 h. After the reaction mixture was evaporated under reduced pressure, the crude methyl 2-(benzyloxycarbonylamino)-3-(1-methylcyclohexyl)propanoate was used directly in the next step without further purification. MS ESI +ve m/z 356 (M+Na).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08487108B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_07 |
|---|
| ORD ID | ord-6236388c73a9446e86fe57190f3c8112 |
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| 출처 메모 | uspto-grants-2013_07 |
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