Methylamine → Benzyl 1-(methylamino)-3-(1-methylcyclohexyl)propan-2-ylcarbamate

HRID 451789노트

반응식

HRID 451789 반응식
CS(O[CH2:6][CH:7]([NH:16][C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])[CH2:8][C:9]1([CH3:15])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)(=O)=O.[CH3:27][NH2:28]>C1COCC1.CCO>[CH3:27][NH:28][CH2:6][CH:7]([NH:16][C:17](=[O:18])[O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:8][C:9]1([CH3:15])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

참가 물질

5

반응물 2

HCID 6329MethylamineHCID 866394482-(Benzyloxycarbonylamino)-3-(1-methylcyclohexyl)propyl methanesulfonate

생성물 1

HCID 59201479Benzyl 1-(methylamino)-3-(1-methylcyclohexyl)propan-2-ylcarbamate

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
70 °C

실험 절차

A mixture of 2-(benzyloxycarbonylamino)-3-(1-methylcyclohexyl)propyl methanesulfonate in 16 mL of THF, and 10 mL of 33% wt. methylamine in EtOH was heated at 70° C. for 3 h. After cooling to rt, the reaction mixture was evaporated under reduced pressure. The crude benzyl 1-(methylamino)-3-(1-methylcyclohexyl)propan-2-ylcarbamate was used directly in the next step without further purification. MS ESI +ve m/z 319 (M+H).

후처리

  1. temperatureAfter cooling to rt
  2. customthe reaction mixture was evaporated under reduced pressure
  3. customThe crude benzyl 1-(methylamino)-3-(1-methylcyclohexyl)propan-2-ylcarbamate was used directly in the next step without further purification

출처 및 근거

ORD 기록
ord-8c932ee858c047c6af60dedc3a488867
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08487108B2

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