HCID 86639452, 화합물 → HCID 86639453, 화합물

HRID 451832노트

반응식

HRID 451832 반응식
[N:1]([CH2:4][C@@H:5]([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:6][C@@H:7]1[CH2:13][CH2:12][CH2:11][CH2:10][O:9][CH2:8]1)=[N+]=[N-]>CO.[Pd]>[NH2:1][CH2:4][C@@H:5]([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:19])([CH3:18])[CH3:20])[CH2:6][C@@H:7]1[CH2:13][CH2:12][CH2:11][CH2:10][O:9][CH2:8]1

참가 물질

4

반응물 1

HCID 86639452HCID 86639452, 화합물

생성물 1

HCID 86639453HCID 86639453, 화합물수율 83%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Above tert-butyl (S)-1-azido-3-((S)-oxepan-3-yl)propan-2-ylcarbamate was hydrogenated under H2 (40 psi), catalyzed by 10% Pd/C, in MeOH for 1 h. The catalyst was filtered off and concentrated to give tert-butyl (S)-1-amino-3-((S)-oxepan-3-yl)propan-2-ylcarbamate (55 mg, 83% over 2 steps). MS ESI +ve m/z 273 (M+H).

후처리

  1. filtrationThe catalyst was filtered off
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7b21db0de2a04b81b3ea880139e01bb0
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08487108B2

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