(R)-tert-butyl 3-((R)-1-(3-chlorophenyl)-1-(2-ethoxy-2-oxoethoxy)ethyl)piperidine-1-carboxylate → ethyl 2-((R)-1-(3-chlorophenyl)-1-((R)-piperidin-3-yl)ethoxy)acetate

HRID 451913

반응식

HRID 451913 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C@@:8]([C@@H:17]2[CH2:22][CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18]2)([O:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH3:9])[CH:5]=[CH:6][CH:7]=1>CC#N>[Cl:1][C:2]1[CH:3]=[C:4]([C@@:8]([C@@H:17]2[CH2:22][CH2:21][CH2:20][NH:19][CH2:18]2)([O:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH3:9])[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 59201464(R)-tert-butyl 3-((R)-1-(3-chlorophenyl)-1-(2-ethoxy-2-oxoethoxy)ethyl)piperidine-1-carboxylate

생성물 1

HCID 59201559ethyl 2-((R)-1-(3-chlorophenyl)-1-((R)-piperidin-3-yl)ethoxy)acetate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of (R)-tert-butyl 3-((R)-1-(3-chlorophenyl)-1-(2-ethoxy-2-oxoethoxy)ethyl)piperidine-1-carboxylate (0.0580 g, 0.136 mmol), 2 NHCl (50 mL), and CH3CN (50 mL) was vigorously stirred at rt for 24 h. After the reaction mixture was evaporated under reduced pressure, the crude product ethyl 2-((R)-1-(3-chlorophenyl)-1-((R)-piperidin-3-yl)ethoxy)acetate was directly used in the next step without further purification. MS ESI +ve m/z 328 (M+H).

후처리

  1. customAfter the reaction mixture was evaporated under reduced pressure
  2. customthe crude product ethyl 2-((R)-1-(3-chlorophenyl)-1-((R)-piperidin-3-yl)ethoxy)acetate was directly used in the next step without further purification

출처 및 근거

ORD 기록
ord-294cfc7ebb864716a59f1c36a94f5412
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08487108B2

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