Water → 2-(methoxymethyl)-1H-benzimidazole

HRID 452189노트

반응식

HRID 452189 반응식
Cl[CH2:2][C:3]1[NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[CH3:12][OH:13].C[O-].[Na+].O>CO>[CH3:12][O:13][CH2:2][C:3]1[NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 785712-ChloromethylbenzimidazoleHCID 23694274Sodium methanolate methanol

생성물 1

HCID 2429502-(methoxymethyl)-1H-benzimidazole수율 19%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-Chloromethylbenzimidazole (1.67 g, 10 mmol) was suspended in methanol (34 mL), 28% sodium methoxide methanol solution (9.6 mL, 50 mmol) and water (50 mL) were added, and the mixture was stirred at room temperature for 20 min. The precipitated solid was collected by filtration, and purified by silica gel column chromatography (chloroform/methanol=100/0 to 93/7) to give the title compound (303 mg, 19%).

후처리

  1. filtrationThe precipitated solid was collected by filtration
  2. custompurified by silica gel column chromatography (chloroform/methanol=100/0 to 93/7)

출처 및 근거

ORD 기록
ord-531e5954d5dc4528ad35a8dfe02b238b
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486980B2

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