3-(2-Hydroxyethyl)-1-{4-nitro-2-[(1E)-prop-1-en-1-yl]phenyl}pyridin-2(1H)-one → 1-(4-Amino-2-propyl phenyl)-3-(2-hydroxyethyl)pyridin-2(1H)-one

HRID 452237노트

반응식

HRID 452237 반응식
[OH:1][CH2:2][CH2:3][C:4]1[C:5](=[O:22])[N:6]([C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][C:11]=2/[CH:19]=[CH:20]/[CH3:21])[CH:7]=[CH:8][CH:9]=1.[H][H]>C1COCC1.[Pd]>[NH2:16][C:13]1[CH:14]=[CH:15][C:10]([N:6]2[CH:7]=[CH:8][CH:9]=[C:4]([CH2:3][CH2:2][OH:1])[C:5]2=[O:22])=[C:11]([CH2:19][CH2:20][CH3:21])[CH:12]=1

참가 물질

5

반응물 2

HCID 595366073-(2-Hydroxyethyl)-1-{4-nitro-2-[(1E)-prop-1-en-1-yl]phenyl}pyridin-2(1H)-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 595366101-(4-Amino-2-propyl phenyl)-3-(2-hydroxyethyl)pyridin-2(1H)-one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

520 mg (1.73 mmol) of the compound from Example 46A are dissolved in 10 ml of THF. 30 mg of palladium on carbon are added, and the mixture is hydrogenated at RT in a hydrogen atmosphere under atmospheric pressure. The mixture is then filtered through kieselguhr, the filter cake is washed three times with THF and the filtrate is freed from the solvent. The reaction product is reacted further without further purification. This gives 471 mg (89% of theory) of the desired product.

후처리

  1. filtrationThe mixture is then filtered through kieselguhr
  2. washthe filter cake is washed three times with THF
  3. customThe reaction product is reacted further without further purification

출처 및 근거

ORD 기록
ord-e4fe05ddb33f4d29a97eb634e14e236c
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08487111B2

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