Methyl 4-bromo-5-fluoro-2-hydroxybenzoate → 5-Bromo-4-fluoro-2-(hydroxymethyl)phenol

HRID 452464노트

반응식

HRID 452464 반응식
[Br:1][C:2]1[C:11]([F:12])=[CH:10][C:5]([C:6](OC)=[O:7])=[C:4]([OH:13])[CH:3]=1>C1COCC1>[Br:1][C:2]1[C:11]([F:12])=[CH:10][C:5]([CH2:6][OH:7])=[C:4]([OH:13])[CH:3]=1

참가 물질

3

반응물 1

HCID 66887268Methyl 4-bromo-5-fluoro-2-hydroxybenzoate

생성물 1

HCID 671560275-Bromo-4-fluoro-2-(hydroxymethyl)phenol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Preparation according to Preparation 21, using methyl 4-bromo-5-fluoro-2-hydroxybenzoate (2.1 g, 8.4 mmol), borane tetrahydrofuran complex (31.0 ml, 31.0 mmol) and dry THF. Yield: 3.3 g (not pure). ESIMS: m/z 221 (M+H)+, 219 (M+H)+.

후처리

  1. customPreparation
  2. customaccording to Preparation 21

출처 및 근거

ORD 기록
ord-d440b9dd68c9435483e88b2a7a1d81b5
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492372B2

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