Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-Bromo-2-methyl-N-(2,2,2-trifluoro-ethyl)-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Ethanamine, 2,2,2-trifluoro- | HCID 9773 | — |
| 반응물 | 4-Bromo-2-methylbenzoic acid | HCID 99570 | — |
| 반응물 | 1-(3-Diethylaminopropyl)-3-ethylcarbodiimide hydrochloride | HCID 9964512 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Bromo-2-methyl-N-(2,2,2-trifluoro-ethyl)-benzamide | HCID 66784310 | 58.1% |
반응 단계
In a solution of 5.00 g of 4-bromo-2-methyl benzoic acid and 3.45 g of 2,2,2-trifluoroethylamine in 30 ml of N,N-dimethylformamide, 5.79 g of 1-[3-(diethylamino)propyl]-3-ethylcarbodiimide hydrochloride was added with stirring at room temperature, and stirred at the same temperature for 1.5 hour. After the completion of the reaction, 80 ml of water was added, and precipitated crystal was filtered off, washed with water and dried to obtain 4.00 g of the aimed product as white crystal.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08492311B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-ce9d8834890c497b84e596722dc2eec6 |
| 출처 메모 | uspto-grants-2013_07 |