Toluene → HCID 24855179, 화합물

HRID 452585노트

반응식

HRID 452585 반응식
[C:1]1([CH:7]2[S:12][CH2:11][CH2:10][NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:14]1[C:23]2[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=2)[N:17]=[CH:16][N:15]=1.C(=O)([O-])[O-].[K+].[K+].C1(C)C=CC=CC=1>CC(O)C>[CH3:25][O:24][C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][C:20]=1[O:26][CH3:27])[N:17]=[CH:16][N:15]=[C:14]2[N:9]1[CH2:10][CH2:11][S:12][CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8]1

참가 물질

6

반응물 4

HCID 1140TolueneHCID 11430Potassium CarbonateHCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 50041992-phenylthiomorpholine

생성물 1

HCID 24855179HCID 24855179, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
180 °C

실험 절차

2-Phenyl-thiomorpholine (1 mole equivalent), 4-Chloro-6,7-dimethoxy-quinazoline (1 mole equivalent) and potassium carbonate (1 mole equivalent) were added to a 1:1 mixture of toluene and 2-propanol, corresponding to a final concentration of about 0.5 molar. The reaction mixture was heated in a microwave oven at 180° C. for 15 minutes, and filtrated. The solvent was removed under vacuum and the resultant solid was subjected to preparative LC-MS-purification. Fractions containing the product were collected, pooled and evaporated in vacuo to give the product.

후처리

  1. filtrationfiltrated
  2. customThe solvent was removed under vacuum
  3. additionFractions containing the product
  4. customwere collected
  5. customevaporated in vacuo
  6. customto give the product

출처 및 근거

ORD 기록
ord-e3fbcc95693f48cda2fa4a33eb313089
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492394B2

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