3-Fluorobenzyl isocyanate → 2-(2,3-dihydro-1-benzofuran-5-ylcarbonyl)-N-(3-fluorobenzyl)hydrazinecarboxamide

HRID 452601노트

반응식

HRID 452601 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([NH:12][NH2:13])=[O:11])=[CH:9][C:4]=2[CH2:3][CH2:2]1.[F:14][C:15]1[CH:16]=[C:17]([CH:22]=[CH:23][CH:24]=1)[CH2:18][N:19]=[C:20]=[O:21]>N1C=CC=CC=1.C(OCC)(=O)C>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([NH:12][NH:13][C:20]([NH:19][CH2:18][C:17]3[CH:22]=[CH:23][CH:24]=[C:15]([F:14])[CH:16]=3)=[O:21])=[O:11])=[CH:9][C:4]=2[CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 6434993-Fluorobenzyl isocyanateHCID 185264692,3-Dihydro-1-benzofuran-5-carbohydrazide

생성물 1

HCID 686644512-(2,3-dihydro-1-benzofuran-5-ylcarbonyl)-N-(3-fluorobenzyl)hydrazinecarboxamide수율 65%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 2,3-dihydro-1-benzofuran-5-carbohydrazide (0.50 g, 2.81 mmol) and 3-fluorobenzyl isocyanate (0.85 g, 5.61 mmol) in pyridine (5 mL) was stirred at room temperature for 3 days. The reaction mixture was diluted with ethyl acetate, washed with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was washed with ethyl acetate to give the title compound (0.60 g, yield 65%) as colorless crystals.

후처리

  1. washwashed with water and saturated brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure
  4. washThe residue was washed with ethyl acetate

출처 및 근거

ORD 기록
ord-70988a3b6cb647c2971100800c3cb15f
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492378B2

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