4-(Methylthio)phenylboronic acid → Methyl 3-[4-(methylthio)phenyl]-1-benzofuran-5-carboxylate

반응식

Br[C:2]1[C:6]2[CH:7]=[C:8]([C:11]([O:13][CH3:14])=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH:3]=1.[CH3:15][S:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][CH:18]=1>>[CH3:15][S:16][C:17]1[CH:22]=[CH:21][C:20]([C:2]2[C:6]3[CH:7]=[C:8]([C:11]([O:13][CH3:14])=[O:12])[CH:9]=[CH:10][C:5]=3[O:4][CH:3]=2)=[CH:19][CH:18]=1

참가 물질

반응물 2

HCID 27339594-(Methylthio)phenylboronic acid

HCID 22481688Methyl 3-bromo-1-benzofuran-5-carboxylate

생성물 1

HCID 44482027Methyl 3-[4-(methylthio)phenyl]-1-benzofuran-5-carboxylate수율 92%

실험 절차

In the same manner as in Reference Example 19 and using methyl 3-bromo-1-benzofuran-5-carboxylate instead of methyl 3-iodoimidazo[1,2-a]pyridine-6-carboxylate and 4-(methylthio)phenylboronic acid instead of (4-methoxyphenyl)boronic acid, the title compound (yield 92%) was obtained as colorless crystals.

출처 및 근거

ORD 기록: ord-a4d66102a7ea47b59eab07558e873a3c
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08492378B2

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