3-(3-Fluorophenyl)propionic acid → 2-(2,3-Dihydro-1-benzofuran-5-yl)-5-[2-(3-fluorophenyl)ethyl]-1,3,4-oxadiazole

HRID 452702노트

반응식

HRID 452702 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([NH:12][NH2:13])=[O:11])=[CH:9][C:4]=2[CH2:3][CH2:2]1.[F:14][C:15]1[CH:16]=[C:17]([CH2:21][CH2:22][C:23](O)=O)[CH:18]=[CH:19][CH:20]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[O:11][C:23]([CH2:22][CH2:21][C:17]4[CH:18]=[CH:19][CH:20]=[C:15]([F:14])[CH:16]=4)=[N:13][N:12]=3)=[CH:9][C:4]=2[CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 27374893-(3-Fluorophenyl)propionic acidHCID 185264692,3-Dihydro-1-benzofuran-5-carbohydrazide

생성물 1

HCID 445903802-(2,3-Dihydro-1-benzofuran-5-yl)-5-[2-(3-fluorophenyl)ethyl]-1,3,4-oxadiazole수율 59%

실험 절차

In the same manner as in Example 14 and using 2,3-dihydro-1-benzofuran-5-carbohydrazide instead of 1H-benzotriazole-5-carbohydrazide and 3-(3-fluorophenyl)propionic acid instead of 3-(3-cyanophenyl)propionic acid, the title compound (yield 59%) was obtained as colorless crystals.

출처 및 근거

ORD 기록
ord-7071985ea8d54a5986ab828e97353e5d
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492378B2

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