1-Bromo-2-Chloroethane → 1-(2,2-Difluorobenzo[D][1,3]dioxol-5-YL)cyclopropanecarbonitrile

참여 물질

역할	이름	HCID	투입량
반응물	1-Bromo-2-Chloroethane	HCID 7849	—
반응물	2,2-Difluoro-1,3-benzodioxole-5-acetonitrile	HCID 20311384	—
반응물	1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonitrile Sodium hydroxide	HCID 67315152	—
촉매	Benzyl triethylammonium chloride	HCID 66133	—
용매	Water	HCID 962	—
생성물	1-(2,2-Difluorobenzo[D][1,3]dioxol-5-YL)cyclopropanecarbonitrile	HCID 57446150	—

반응 조건

온도	70 °C

반응 단계

1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonitrile Sodium hydroxide (50% aqueous solution, 10 mL) was slowly added to a mixture of crude (2,2-difluoro-benzo[1,3]dioxol-5-yl)-acetonitrile, benzyltriethylammonium chloride (3.00 g, 15.3 mmol), and 1-bromo-2-chloroethane (4.9 g, 38 mmol) at 70° C. The mixture was stirred overnight at 70° C. and the reaction mixture was diluted with water (30 mL) and extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate and evaporated to dryness to give crude 1-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonitrile, which was used directly in the next step.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08541453B2
출처 데이터셋	uspto-grants-2013_09
ORD ID	ord-7ed85289fe0e4e46950710b1bf82c8b3
출처 메모	uspto-grants-2013_09