Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroacetyl chloride → 6-Bromo-2-chloromethyl-3-(2-chlorophenyl)-3H-quinazolin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroacetyl chloride | HCID 6577 | — |
| 반응물 | 2-amino-5-bromo-N-(2-chlorophenyl)benzamide | HCID 22316548 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 6-Bromo-2-chloromethyl-3-(2-chlorophenyl)-3H-quinazolin-4-one | HCID 22316575 | 83% |
반응 단계
Prepared according to Procedure B with 1b (500 mg, 1.54 mmol) and chloroacetyl chloride (0.37 mL, 4.61 mmol) in acetic acid (10 mL). Purified by recrystallization from isopropanol to afford 490 mg of an off-white solid (83%). 1H NMR (CDCl3) δ: 8.43 (d, J=2.3 Hz, 1H); 7.91 (dd, J=2.3, 8.7 Hz, 1H); 7.67 (d, J=8.7 Hz, 1H); 7.60-7.65 (m, 1H); 7.47-7.56 (m, 2H); 7.52 (t, J=5.3 Hz, 1H); 7.47-7.56 (m, 1H); 4.37 (d, J=12 Hz, 1H), 4.06 (d, J=12 Hz, 1H). MS (ES): m/z 385.0 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08492389B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-227aaacdbe66497989b00b31b0e8eb4b |
| 출처 메모 | uspto-grants-2013_07 |