Chloroacetyl chloride → 5-Chloro-2-chloromethyl-3-(2-methoxyphenyl)-3H-quinazolin-4-one

참여 물질

역할	이름	HCID	투입량
반응물	Chloroacetyl chloride	HCID 6577	—
반응물	2-amino-6-chloro-N-(2-methoxyphenyl)benzamide	HCID 22316549	—
용매	Acetic Acid	HCID 176	—
생성물	5-Chloro-2-chloromethyl-3-(2-methoxyphenyl)-3H-quinazolin-4-one	HCID 22316590	28%

반응 단계

Prepared according to Procedure B with 1l (2.6 g, 9.41 mmol) and chloroacetyl chloride (2.2 mL, 28.2 mmol) in acetic acid (40 mL). Purified by chromatography in CH2Cl2, followed by recrystallization from isopropanol to afford 874 mg of a pale yellow solid (28%). 1H NMR (CDCl3) δ: 7.55-7.74 (m, 2H); 7.47-7.54 (m, 2H); 7.34 (dd, J=1.7, 7.8 Hz, 1H); 7.13 (dt, J=1.2, 7.7 Hz, 1H); 7.08 (dd, J=1.0, 8.4 Hz, 1H); 4.29 (d, J=12 Hz, 1H); 4.11 (d, J=12 Hz, 1H); 3.80 (s, 3H). MS (ES): m/z 335.0 (M+).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08492389B2
출처 데이터셋	uspto-grants-2013_07
ORD ID	ord-c4b552d6bd4447b6a2a1207c3ac4b14b
출처 메모	uspto-grants-2013_07