참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Metformin Hydrochloride | HCID 14219 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 178476642 | HCID 178476642 | 73% |
반응 단계
20.0 g (1 equivalent) of metformin hydrochloride and 30 Ml of water, and then 10 Ml (1.45 equivalents) of acetic acid were added to a reactor, and stirred for 2 hours at 30° C. to dissolve thoroughly. Then 1.23 g (1.5 equivalents) of aqueous solution of sodium hydroxide was added to the reaction solution. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 16.7 g of metformin acetate (yield: 73.0%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08541474B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-6fb44aec1ba6457d8f8eea270e485c9a |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
