Thionyl Chloride → 3-Nitro-5-(trifluoromethyl)benzoyl chloride

반응식

[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:12]=1)[C:7](O)=[O:8])([O-:3])=[O:2].S(Cl)([Cl:19])=O>>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:12]=1)[C:7]([Cl:19])=[O:8])([O-:3])=[O:2]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 6166023-Nitro-5-(trifluoromethyl)benzoic acid

생성물 1

HCID 226083993-Nitro-5-(trifluoromethyl)benzoyl chloride

실험 절차

A solution of 3-nitro-5-(trifluoromethyl)benzoic acid (2.00 g, 8.51 mmol) in thionyl chloride (12.4 ml, 170 mmol) was heated at 90° C. for 2 hours. The solution was cooled to room temperature, concentrated, and azeotroped with toluene to provide 3-nitro-5-(trifluoromethyl)benzoyl chloride as a liquid.

후처리

concentrationconcentrated
customazeotroped with toluene

출처 및 근거

ORD 기록: ord-b4a247cdd43344568779fb562d08b5ea
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08492371B2

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