Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → HCID 178476642, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Metformin Hydrochloride | HCID 14219 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | HCID 178476642 | HCID 178476642 | 92.4% |
반응 단계
0.4 L of water, 241.50 g of sodium hydroxide, 9 L of acetone and 1 Kg of metformin hydrochloride were added to a 20 L reactor, and stirred for 2 hours and 40 minutes at room temperature. The resulting crystal was filtered and washed with acetone. 0.2 L of water and 1 L of acetic acid were added and stirred. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 1,056 g of metformin acetate (yield: 92.4%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541474B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-050d89d8ac0a418c87d5623f7c8d671e |
| 출처 메모 | uspto-grants-2013_09 |