Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Metformin Hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | HCID 178484382 | HCID 178484382 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | Metformin Hydrochloride | HCID 14219 | 76.4% |
반응 단계
500 mg of metformin free base was dissolved in 30 Ml of acetone, and then 280 Ml of concentrated hydrochloric acid was added, and stirred for 2 hours at room temperature. The resulting crystal was filtered and washed with acetone, and then dried with heated air at 70° C. to obtain 490 mg of metformin hydrochloride (yield: 76.4%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541474B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-bb7f28c0f0144c43ad84ff9519be4688 |
| 출처 메모 | uspto-grants-2013_09 |