Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Hydroxyindole → 1H-Indole, 5-[[6-[(phenylmethoxy)methyl]-4-pyrimidinyl]oxy]-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Hydroxyindole | HCID 16054 | — |
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | 4-((Benzyloxy)methyl)-6-chloropyrimidine | HCID 53421259 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1H-Indole, 5-[[6-[(phenylmethoxy)methyl]-4-pyrimidinyl]oxy]- | HCID 59394260 | — |
반응 단계
To a solution of 5-hydroxy indole (1.33 g, 10 mmol) and 4-benzyloxymethyl-6-chloro-pyrimidine (2.35 g, 10 mmol) in acetonitrile (20 mL) is added DBU. After 16 h at rt the solution is concentrated under reduced pressure. The residue is purified by FCC (EtOAc/Heptane from 0% to 40%) to give 5-(6-benzyloxymethyl-pyrimidin-4-yloxy)-1H-indole. MS (ESI) m/z 447.0 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08492393B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-7cb274b658ab4bdb816a8f488bb21c0a |
| 출처 메모 | uspto-grants-2013_07 |