Pyridine → HCID 66725717, 화합물

반응식

N[CH:2]1[CH2:6][N:5](C(CC)C(N)=[O:9])[C:4](=[O:13])[CH2:3]1.CO[C:16]1([O:21][CH3:22])[CH2:20][CH2:19][CH2:18]O1.N1C=CC=CC=1>CC(O)=O>[NH:5]1[CH2:6][CH2:2][CH2:3][C:4]1=[O:13].[O:21]1[CH:22]=[CH:18][C:19]([OH:9])=[CH:20][CH2:16]1

참가 물질

반응 조건

온도: 70 °C

실험 절차

In a three necked flask, under argon, a suspension of 2-[4-amino-2-oxo-1-pyrrolidinyl]butanamide 393 (6.99 g, 0.037 mol.), dimethoxytetrahydrofurane (5.53 g, 0.041 mol.), pyridine (50.6 ml) and AcOH (36 ml) is warmed to 70° C. and dissolution occurs. After 2 h at this temperature, the reaction is cooled down to room temperature, concentrated in vacuo and the crude product is purified by chromatography on silicagel (CH2Cl2/MeOH: 95/05 (v/v)) to afford 223 as an oil (2.67 g, 30.1%).

후처리

dissolutiondissolution
temperaturethe reaction is cooled down to room temperature
concentrationconcentrated in vacuo
customthe crude product is purified by chromatography on silicagel (CH2Cl2/MeOH: 95/05 (v/v))

출처 및 근거

ORD 기록: ord-c3bdaacbdf5a44e393d526beca54a6a6
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08492416B2

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참가 물질

반응물 3

HCID 1049Pyridine

HCID 11788317Dimethoxytetrahydrofurane

HCID 22386994HCID 22386994, 화합물

생성물 1

HCID 66725717HCID 66725717, 화합물수율 39.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도: 70 °C

실험 절차

후처리

dissolutiondissolution
temperaturethe reaction is cooled down to room temperature
concentrationconcentrated in vacuo
customthe crude product is purified by chromatography on silicagel (CH2Cl2/MeOH: 95/05 (v/v))

출처 및 근거

ORD 기록: ord-c3bdaacbdf5a44e393d526beca54a6a6
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08492416B2

반응 노트

불러오는 중…