Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclobutanecarbonyl chloride → 2-(Cyclobutanecarbonylamino)-4-methylthiazole-5-carboxylic acid benzylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclobutanecarbonyl chloride | HCID 78705 | — |
| 반응물 | N-Benzyl-2-imino-4-methyl-2,3-dihydro-1,3-thiazole-5-carboximidic acid | HCID 210824 | — |
| 생성물 | 2-(Cyclobutanecarbonylamino)-4-methylthiazole-5-carboxylic acid benzylamide | HCID 59369692 | 46% |
반응 단계
Following the procedure as described in Example 2, making variations only as required to use cyclobutanecarbonyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 46% yield; 1H NMR (DMSO-ds, 300 MHz) δ 7.38-7.25 (m, 4H), 5.96 (s, br, 1H), 4.58-4.50 (m, 2H), 3.25-3.14 (m, 1H), 2.53 (s, 3H), 2.42-1.90 (m, 6H); MS (ES+) m/z 330.0 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541457B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-b7ab29657b9a43879daad28b645ddbb0 |
| 출처 메모 | uspto-grants-2013_09 |