2-Phenyl-4-carboxythiazole → N-(2-(6-(morpholinomethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-phenylthiazole-4-carboxamide

HRID 453313노트

반응식

HRID 453313 반응식
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:9]=[C:10]3[N:16]=[C:15]([C:17]4[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=4[NH2:19])[S:14][C:11]3=[N:12][CH:13]=2)[CH2:3][CH2:2]1.[C:24]1([C:30]2[S:31][CH:32]=[C:33]([C:35](O)=[O:36])[N:34]=2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>O>[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:9]=[C:10]3[N:16]=[C:15]([C:17]4[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=4[NH:19][C:35]([C:33]4[N:34]=[C:30]([C:24]5[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=5)[S:31][CH:32]=4)=[O:36])[S:14][C:11]3=[N:12][CH:13]=2)[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 1389282-Phenyl-4-carboxythiazoleHCID 585518812-(6-(Morpholinomethyl)thiazolo[5,4-b]pyridin-2-yl)aniline

생성물 1

HCID 46245045N-(2-(6-(morpholinomethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-phenylthiazole-4-carboxamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The title compound was prepared according to amide synthesis general method A, utilizing 2-(6-(morpholinomethyl)thiazolo[5,4-b]pyridin-2-yl)aniline and 2-phenylthiazole-4-carboxylic acid. The product was isolated by precipitation by the addition of water, triturated with hot methanol, dissolved in CH2Cl2, washed with dilute NaHCO3, concentrated and purified by silica gel chromatography (gradient 0 to 10% methanol in CH2Cl2). MS Calcd for C27H23N5O2S2: 513.13. Found (M+H)+ m/z=514.

후처리

  1. customtriturated with hot methanol
  2. dissolutiondissolved in CH2Cl2
  3. washwashed with dilute NaHCO3
  4. concentrationconcentrated
  5. custompurified by silica gel chromatography (gradient 0 to 10% methanol in CH2Cl2)

출처 및 근거

ORD 기록
ord-d450184c5449403a879a71241b7be451
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492401B2

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