2-Hydroxy-3,4,6-trimethylbenzaldehyde → 2,3,5,6-Tetramethylphenol

HRID 453419

반응식

HRID 453419 반응식
[OH:1][C:2]1[C:9]([CH3:10])=[C:8]([CH3:11])[CH:7]=[C:6]([CH3:12])[C:3]=1[CH:4]=O>CO.[C].[Pd]>[CH3:4][C:3]1[C:6]([CH3:12])=[CH:7][C:8]([CH3:11])=[C:9]([CH3:10])[C:2]=1[OH:1]

참가 물질

4

반응물 1

HCID 113211462-Hydroxy-3,4,6-trimethylbenzaldehyde

생성물 1

HCID 106942,3,5,6-Tetramethylphenol수율 12.1%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

2-Hydroxy-3,4,6-trimethylbenzaldehyde (6.58 g, 40.1 mmol) was dissolved in methanol (120 mL), 10% palladium-carbon (50% water-containing product, 1.0 g) was added under hydrogen atmosphere (balloon pressure), and the mixture was stirred at room temperature for 22 hr. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. The precipitated crystals were recrystallized from methanol to give the title compound (0.73 g, yield 12%) as colorless crystals. The mother solution was concentrated under reduced pressure to give second crop (5.10 g, yield 85%).

후처리

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe precipitated crystals were recrystallized from methanol

출처 및 근거

ORD 기록
ord-dc76604064ae4a79a08bba08857ce0dc
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492430B2

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