Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Cyanobenzoyl chloride → 2-(4-Cyanobenzoylamino)-4-methylthiazole-5-carboxylic Acid Benzylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Cyanobenzoyl chloride | HCID 80172 | — |
| 반응물 | N-Benzyl-2-imino-4-methyl-2,3-dihydro-1,3-thiazole-5-carboximidic acid | HCID 210824 | — |
| 생성물 | 2-(4-Cyanobenzoylamino)-4-methylthiazole-5-carboxylic Acid Benzylamide | HCID 59369697 | 23% |
반응 단계
Following the procedure as described in Example 2, making variations only as required to use 4-cyanobenzoyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 23% yield; m.p. 256-258° C.; 1H NMR (DMSO-d6, 300 MHz) δ 8.64 (t, J=5.7 Hz, 1H), 8.19 (d, J=8.2 Hz, 2H), 7.99 (d, J=8.2 Hz, 2H), 7.49-7.18 (m, 5H), 4.37 (d, J=5.7 Hz, 2H), 2.51 (s, 3H); MS (ES+) m/z 377.2 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541457B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-e6742ee856024641a4862b488010a213 |
| 출처 메모 | uspto-grants-2013_09 |