Benzyltrimethylammonium hydroxide → (Z)-N-(4-chlorophenethyl)-4-(2-bromo-4-(2-(methylsulfinyl)-2-(methylthio)vinyl)phenoxy)benzamide

참여 물질

역할	이름	HCID	투입량
반응물	Benzyltrimethylammonium hydroxide	HCID 66854	—
반응물	Methyl (methylsulfinyl)methyl sulfide	HCID 99129	—
반응물	N-(4-chlorophenethyl)-4-(2-bromo-4-formylphenoxy)benzamide	HCID 86643286	—
용매	Tetrahydrofuran	HCID 8028	—
생성물	(Z)-N-(4-chlorophenethyl)-4-(2-bromo-4-(2-(methylsulfinyl)-2-(methylthio)vinyl)phenoxy)benzamide	HCID 86643287	96.1%

반응 조건

온도	70 °C

반응 단계

N-(4-chlorophenethyl)-4-(2-bromo-4-formylphenoxy)benzamide (1.6 g, 3.5 mmol) was diluted with THF (10 mL) followed by the addition of N,N,N-trimethyl(phenyl)methanaminium hydroxide (0.79 ml, 1.7 mmol) and methylsulfinyl (methylthio)methane (0.87 g, 7.0 mmol). The reaction was stirred at 70° C. for 2 hours. The reaction mixture was loaded directly onto a silica gel column and eluted with DCM:MeOH (98:2) to yield (Z)—N-(4-chlorophenethyl)-4-(2-bromo-4-(2-(methylsulfinyl)-2-(methylthio) vinyl)phenoxy)benzamide (1.9 g, 96% yield).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08492437B2
출처 데이터셋	uspto-grants-2013_07
ORD ID	ord-558783616cce47f3bf0a9cc5418151ff
출처 메모	uspto-grants-2013_07