Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,5-Difluorobenzoyl chloride → 2-(3,5-Difluorobenzoylamino)-4-methylthiazole-5-carboxylic Acid Benzylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,5-Difluorobenzoyl chloride | HCID 145600 | — |
| 반응물 | N-Benzyl-2-imino-4-methyl-2,3-dihydro-1,3-thiazole-5-carboximidic acid | HCID 210824 | — |
| 생성물 | 2-(3,5-Difluorobenzoylamino)-4-methylthiazole-5-carboxylic Acid Benzylamide | HCID 59369693 | 48% |
반응 단계
Following the procedure as described in Example 2, making variations only as required to use 3,5-difluorobenzoyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 48% yield; m.p. 84-86° C.; 1H NMR (CDCl3, 300 MHz) δ 7.44-7.24 (m, 7H), 7.01 (tt, J=2.2, 8.4 Hz, 1H), 6.05 (s, 1H), 4.58 (d, J=5.6 Hz, 2H), 2.41 (s, 3H); MS (ES+) m/z 388.1 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541457B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-2b4782e98f7a493b8d1bdc136a33eea3 |
| 출처 메모 | uspto-grants-2013_09 |