Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl chloride, 3,4-dichloro- → 2-(3,4-Dichlorobenzoylamino)-4-methylthiazole-5-carboxylic Acid Benzylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl chloride, 3,4-dichloro- | HCID 76403 | — |
| 반응물 | N-Benzyl-2-imino-4-methyl-2,3-dihydro-1,3-thiazole-5-carboximidic acid | HCID 210824 | — |
| 생성물 | 2-(3,4-Dichlorobenzoylamino)-4-methylthiazole-5-carboxylic Acid Benzylamide | HCID 59369672 | 15% |
반응 단계
Following the procedure as described in Example 2, making variations only as required to use 3,4-dichlorobenzoyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 15% yield; m.p. 212-214° C.; 1H NMR (CD3OD, 300 MHz) δ 8.21 (d, J=2.0 Hz, 1H), 7.93 (dd, J=2.0, 8.4 Hz, 1H), 7.68 (d, J=8.4 Hz, 1H), 7.33-7.23 (m, 5H), 4.50 (s, 2H), 2.54 (s, 3H); MS (ES+) m/z 420.0 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541457B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-0247335befb84638afee45c80231f782 |
| 출처 메모 | uspto-grants-2013_09 |